Distinguished Research Professor of Clinical Chemistry
Michael Oellerich, MD, HonMD, FADLM, FAMM, FFPath (RCPI), FRCPath, is a chemical pathologist and Distinguished Research Professor at the Department of Clinical Pharmacology, Medical Faculty (UMG), George-August University, Göttingen, and a consultant to iMDx, Nashville, Tennessee. He previously served as Lower Saxony Professor of Clinical Chemistry (2012–2017), Chairman of the Department of Clinical Chemistry/Central Laboratory (1991–2012), and Dean of the Faculty of Medicine.
An internationally recognized leader in therapeutic drug monitoring and precision diagnostics, Dr. Oellerich has advanced clinical implementation of cell-free DNA analytics, including cfDNA in oncology and donor-derived cfDNA in transplantation. His record includes more than 500 peer-reviewed publications, an H-index of 81, and over 21,986 citations.
Dr. Oellerich has held presidencies of multiple national and global organizations (IATDMCT, DGLM, DGKL, WASPaLM) and was Editor-in-Chief of Therapeutic Drug Monitoring (2003–2018), where he continues to serve as Associate Editor. His contributions have been recognized with numerous honors, including the Ludolf-Krehl Award, IATDMCT Charles Pippenger Award, WASPaLM Medal of Honor, WASPaLM Gold-Headed Cane, F. McCreary Prize (UBC Health, 2022), and the Claus Roxin Award (2023).
Office
| Assistant: | Kirsten Bornemann | |
| Tel.: | +49 551 39 - 68545 | |
| Email: | michael.oellerich@med.uni-goettingen.de | |
| Medical Faculty (UMG) of the George-August University Göttingen | ||
| Department of Clinical Pharmacology | ||
| Robert-Koch-Straße 40 | ||
| D-37075 Göttingen | ||
| Germany |
Research activities
Specific areas of research currently encompass therapeutic drug monitoring, pharmacokinetics, pharmacogenetics and pharmacodynamics with particular focus on molecular biomarkers to achieve personalized immunosuppression in transplantation (e.g. donor-derived cell-free DNA) as well as genotype-directed cancer care using ctDNA; research recently published in the American Journal of Transplantation (Oellerich M et al, Absolute quantification of donor-derived cell-free DNA as a marker of rejection and graft injury in kidney transplantation: Results from a prospective observational study) was among the top 10% most downloaded papers in 2019.
Research projects
| 1993 - 1995 | SFB 330 |
| Organprotektion | |
| Teilprojekt D8 | |
| Organprotektion: Lipidperoxidation und Cytochrom P-450 Aktivität in der Leber im Ischämieverlauf und nach Reperfusion | |
| Oellerich / Wieland /Schuff-Werner | |
| 1998 - 2000 | SFB 402 |
| Molekulare und Zelluläre Hepaterogastroenterologie | |
| Teilprojekt D 1 | |
| Mechanismen des Konservierungs- / Reperfusionsschadens und dessen Bedeutung für den Funktionserhalt von Leber und Dünndarm des Schweins | |
| Schütz / Oellerich / Wieland / Braun / Ringe | |
| 1999 - 2001 | SFB 500 |
| Maligne Transformation und Tumorprogression | |
| Teilprojekt B1 | |
| Bedeutung der induzierbaren NO-Synthese (iNOS) für die TNF-a-induzierte Apoptose von epithelialen Tumorzellen | |
| Binder / Oellerich | |
| 2001 - 2003 | QLRI-CT-2002-02758-EUPEAH |
| Glucocorticoid Hormone Programming in Early Life and its Impact on Adult Health (EUPEAH) | |
| Oellerich / Armstrong | |
| 2007 - 2012 | BMBF Projekt Indien IND 06/040 |
| Studies on Aspergillus fumigatus proteome for identification of novel unknown immunogens | |
| Oellerich / Asif / Reichard | |
| Sharma / Bhadoria / Katyal / Singh / Kumar | |
| 2012 - 2015 | BMBF Projekt 01ES1102 |
| Biomarker assisted personalized immunosuppression following liver transplantation | |
| Brockmöller / Oellerich / Nashan / Pratschke / Friede / Kollmar / Schemmer | |
| 2015 - 2018 | KMU-Innovativ: Biotechnologie – BioChance, Nr. PtJ 31P9146 (BIO-624-004) |
| Validierung eines GcfDNA-basierten diagnostischen Tests zur frühzeitigen Erkennung von Organschädigungen nach Nierentransplantation | |
| Schütz / Oellerich / Friede / Wieland | |
| 2018 - 2022 | Genome Canada large-scale applied research project (LSARP): Precision Medicine CanPREVENT AMR: Applying Precision Medicine Technologies in Canada to Prevent Antibody Mediated Rejection and Premature Kidney Transplant Loss (273AMR) |
| Keown / Sapir-Pichhadze / Caulfield / Bryan Oellerich (co-investigator) | |
| 2019 - | Cell-free donor-DNA monitored personalized immunosuppression after liver transplantation – a prospective oberservation single center study. |
| Medizinische Hochschule Hannover, Abteilung Gastroenterologie, Hepatologie und Endokrinologie | |
| Tauber / Oellerich / Schütz / Beck | |
| 2021 - 2023 | Donor-derived cell-free DNA for early diagnosis of antibody-mediated rejection (cfDNA-DSA) (NCT 04897438). (Pilotstudie zur prospektiven Evaluation zellfreier Transplant_DNA in der Diagnostik von Patient*innen mit donorspezifischen HLA_Antikörpern nach Nierentransplantation). |
| Charite – Universitätsmedizin Berlin, Abteilung Nephrologie und Intensivmedizin | |
| Budde / Oellerich / Osmanodja / Beck / Bornemann-Kolatzki / Schütz |
Research partners
| Dr. Aylin Akifova | Division of Nephrology and Internal Intensive Care Medicine, Hospital Charité Universitätsmedizin Berlin, Germany |
| Dr. rer.nat. Julia Beck | Chronix Biomedical, Göttingen, Germany |
| Dr. Ortraud Beringer | Department of Pediatrics and Adolescent |
| Dr. med.vet. Kirsten Bornemann-Kolatzki | Chronix Biomedical, Göttingen, Germany |
| Prof. Dr. Klemens Budde | Division of Nephrology and Internal Intensive Care Medicine, Hospital Charité Universitätsmedizin Berlin, Germany |
| PD Dr.med. Dr. rer.nat. Ingrid Birschmann | Institute for Laboratory and Transfusion Medicine, Heart and Diabetes Center NRW, Bad Oeynhausen, Germany |
| Prof. Dr.med. Jürgen Brockmöller | Dept. of Clinical Pharmacology, University Medical Center Göttingen, Germany |
| Prof. Dr.med. Martin Canis | Dept. of Otolaryngology, Hospital of the Ludwig-Maximilians-University (LMU) Munich, Germany |
| Prof. Dr.med. Jan Gummert | Clinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Center NRW, Bad Oeynhausen, Germany |
| Dr. Helena Hansmann | Department of Nephrology, University Hospital Regensburg |
| Prof. Dr. Paul A. Keown, MD | Dept. of Immunology, University of British Columbia, Vancouver, Canada |
| Dr.med. Bilgin Osmanodja | Division of Nephrology and Internal Intensive Care Medicine, Hospital Charité Universitätsmedizin Berlin, Germany |
| Prof. Dr.med. L. Christian Rump | epartment of Internal Medicine / Nephrology, University Medical Center Düsseldorf, Germany |
| Prof. Dr.med. Ekkehard Schütz | Chronix Biomedical, Göttingen, Germany |
| Karen Sherwood, PhD | Dept. of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada |
| Prof. Dr.med. Vedat Schwenger | Clinic for Kidney, Hypertension and Autoimmune Diseases, Katharinenhospital, Klinikum Stuttgart, Germany |
| Dr. med. Dr. b-g Maria Shipkova | Synlab Holding Germany GmbH, Competence Center for Therapeutic Drug Monitoring, Medical Care Center, Leinfelden-Echterdingen, Germany |
| PD Dr.med. Johannes Stegbauer | Department of Internal Medicine / Nephrology, University Medical Center Düsseldorf, Germany |
| PD Dr. Richard Taubert, MD | Dept. of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hanover, Germany |
| Prof. Dr. med. Burkhard Tönshoff | University Children's Hospital Heidelberg, Germany |
| Prof. Philip D. Walson, MD | Dept. of Clinical Pharmacology, University Medical Center Göttingen, Germany |
| Prof. Dr.med. Eberhard Wieland | Synlab Holding Germany GmbH, Competence Center for Therapeutic Drug Monitoring, Medical Care Center, Leinfelden-Echterdingen, Germany |
| Prof. George Yousef, MD, PhD | Department of Laboratory Medicine & Pathobiology - Anatomic Pathology, Toronto General Hospital: University Health Network (UHN), Canada |
| Prof. Dr. Zecher | Department of Nephrology, University Hospital Regensburg |
Teaching
Clinical chemistry lectures, seminars